In 1946, Public Law 588 of the 79th Congress established the Office of Naval Research (ONR). Its mission was to plan, foster and encourage scientific research in support of Naval problems. The establishment of ONR predates the National Science Foundation and initiated the refocusing of scientific infrastructure in the United States following World War II. At the time, ONR was the only source for federal support of basic research in the United States. Dorothy Gilford was one of the first Heads... Source: http://arxiv.org/abs/0710.4768v1
This article is from Indian Journal of Ophthalmology , volume 59 . Abstract The Hutchinson-Gilford progeria (HGP) syndrome is an extremely rare genetic condition characterized by an appearance of accelerated aging in children. The word progeria is derived from the Greek word progeros meaning ‘prematurely old’. It is caused by de novo dominant mutation in the LMNA gene (gene map locus 1q21.2) and characterized by growth retardation and accelerated degenerative changes of the skin,... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214428
byHanumanthappa, Natesh B; Madhusudan, Ganigara; Mahimarangaiah, Jayaranganath; Manjunath, Cholenahally N
This article is from Annals of Pediatric Cardiology , volume 4 . Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging syndrome that results from mutation in the Laminin A gene. This case report of a 12-year-old girl with HGPS is presented for the rarity of the syndrome and the classical clinical features that were observed in the patient. All patients with this condition should undergo early and periodic evaluation for cardiovascular diseases. However, the prognosis... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180988
This article is from Journal of Medical Case Reports , volume 7 . Abstract Introduction: Hutchinson-Gilford progeria syndrome is a rare pediatric genetic syndrome with an incidence of one per eight million live births. The disorder is characterized by premature aging, generally leading to death due to myocardial infarction or stroke at approximately 13.4 years of age. The genetic diagnosis and special clinical manifestation in two Han Chinese siblings observed at our clinic for genetic... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602076
byInternational Multispecialty Journal of Health (IMJH)
Abstract — Hutchinson–Gilford Progeria Syndrome is a rare genetic disorder characterized by premature aging involving the skin, bones, heart, and blood vessels. We report a five year old female child with clinical manifestations characteristic of this syndrome. This child had a senile look with large cranium, frontal bossing, sparse light brown hair and dilated visible veins over the scalp. Other features were prominent eyes, beaked nose, micrognathia, sclerodermatous changes in both feet... Topics: Hutchinson, Gilford Progeria Syndrome, Hypothyroidism.
This article is from Journal of Pediatric Neurosciences , volume 8 . Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a very rare genetic disorder characterized by premature ageing, severe growth failure, and very early onset atherosclerosis. Psychologically and emotionally child-like, these patients suffer from physiological changes of old age. Early and progressive atherosclerosis of intra-cranial vessels in HGPS patients, along with a thin skin and fragile vessels, make these... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783731